On March 27, 2001, plaintiffs’ decedent Leonel Garza, 71, was given a one-week supply of 25-milligram Vioxx tablets for his arm pain. Vioxx, a painkiller made and marketed by Merck until September 2004, is a COX-2 selective non-steroidal anti-inflammatory drug. Garza resided in Rio Grande City, Texas.